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Generic Cabergoline tablets are also used by bodybuilders in professional bodybuilding and weight-training athletes during anabolic steroid cycles to increase muscle massand to enhance energy stores (Lane et al., 2014). Tribulus terrestris was initially thought to be the main product of the plant (Grundfors, 2014). However, research has shown that an extract of tramuline from the plant known as tribulus terrestris also contains anabolic steroid metabolites and is well-tolerated in humans (Bruhlik et al., 2012). Additionally, trabulsan also has potential anti-cancer properties (De Sousa et al., 2015). Dosages and Toxicity In rats, tramuline is metabolized to the anabolic steroid tranylcypromine (TPC) where it is then excreted (Beard et al., 1979). Because of its aqueous solubility, tramuline does not easily pass into the human body and can be absorbed through the gastrointestinal tract (Beardy et al., 1981). In rats, long-term oral administration of tramuline produced adverse effects including decreased body weight, hyperlipidemia, decreased sex drive, impotence and increased hepatic triglyceride (HPT) content (De Sousa et al., 1999). These effects were reversed by the use of a tranylcypromine derivative called tranylcypromine alfa (TCC) (Bruhlik et al., 2012). A rat study using oral administration of two doses of tricyclic antidepressants (TCAs; Zoloft, sertraline) showed that it inhibited the release of prolactin and testosterone from epididymal spermatozoa. These antidepressant-induced alterations are thought to be a direct effect of these drugs on the hypothalamic–pituitary–gonadal axis and have been documented to affect the reproductive performance of rats (Bruhlik et al., 2001). Tramuline's interaction with other drugs and drugs of abuse has not been studied. However, tramuline is a potent inducer of CYP2A4 in humans (Grundfors et al., 2016). In another study, tramuline did not affect the metabolic profile of ethanol as shown by a single oral dose assessment. Because tramuline reduces CYP2A4 activity in humans, its use in drug-drug interactions remains controversial (Nogut et al., 2017). The dose-related changes in the pituitary gland are unknown because studies using animals Similar articles: